Recombinant Influenza Vaccines

Recombinant Influenza Vaccines

This review covers the problems encountered in the construction and production of new recombinant influenza vaccines. New approaches to the development of influenza vaccines are investigated; they include reverse genetics methods, production of virus-like particles, and DNA- and viral vector-based vaccines. Such approaches as the delivery of foreign genes by DNA- and viral vector-based vaccines...

New options for influenza vaccines: quadrivalent, recombinant, and cell culture.

Bacterially Produced Recombinant Influenza Vaccines Based on Virus-Like Particles

Although current influenza vaccines are effective in general, there is an urgent need for the development of new technologies to improve vaccine production timelines, capacities and immunogenicity. Herein, we describe the development of an influenza vaccine technology which enables recombinant production of highly efficient influenza vaccines in bacterial expression systems. The globular head d...

Universal influenza vaccines: Shifting to better vaccines

Influenza virus causes acute upper and lower respiratory infections and is the most likely, among known pathogens, to cause a large epidemic in humans. Influenza virus mutates rapidly, enabling it to evade natural and vaccine-induced immunity. Furthermore, influenza viruses can cross from animals to humans, generating novel, potentially pandemic strains. Currently available influenza vaccines i...

Influenza vaccines Richard

1. Abstract 2. Introduction 2.1. Mechanisms of influenza virus evolution 2.2. Resurgence of influenza vaccinology 3. Current influenza vaccines 3.1. Inactivated vaccines 3.2. Live attenuated vaccines 3.3. Limitations of current influenza vaccine strategies 4. Reverse genetics 4.1. Creation of high-growth reassortant vaccine strains 4.2. Other uses of reverse genetics in influenza vaccines 4.3. ...